Mythic +
Firepower Nurse Harley A+
Harley Quinn
Birds of Prey Birds of Prey
Arkham's Most Wanted Arkham's Most Wanted
Weapon Master Weapon Master

Quantum's Take

Nurse Harley has proven herself to be a formidable champion in the Arkham's Most Wanted lineup. The issue is she costs more than any champion in the game to max out, as she is the current VIP track reward, and her legacy piece (which is also paywalled) is 100% required for her to perform as intended. I really like her kit and the damage over time mechanics, and she's a visually fun champion with the syringe gun. We can only hope she becomes more affordable over time.

Damage Type

Physical

Sources where available

VIP Perks

RavenHrt's Transmute Priorities

Physical PEN, Energy Gain Bonus, ATK, Crit Rate

Recommended Legacy Pieces

Psycho Syringe
A tier

Psycho Syringe

Tectonic Disruptor
B tier

Tectonic Disruptor

Gas Derringer
C tier

Gas Derringer

Multiversal Force Upgrades

Insanity Erosion - Enhanced
Insanity Erosion - Enhanced
Reduces cooldown of [Insanity Erosion].
Madness Actualization - Enhanced
Madness Actualization - Enhanced
Increases Nurse Harley's Crit DMG.
Arkham's Awakening - Enhanced
Arkham's Awakening - Enhanced
Increases Nurse Harley's Crit Rate.

Ultimate

Corrosive Sanity
Corrosive Sanity
Nurse Harley enters [Self-Actualization] for [13s]. While in this state, her basic attacks fire corrosive shots, each dealing physical damage equal to [%] of her Attack and inflicting [2] stacks of [Corrosion].

Global Skill

Adrenaline Frenzy
Adrenaline Frenzy
Increases all Champions' ATK by [%], with an additional [%] for [Firepower] Champions.

Skills

Insanity Erosion
Insanity Erosion
Deals physical damage equal to [%] of Attack and inflicts [4] stacks of [Corrosion].
Madness Actualization
Madness Actualization
Nurse Harley's active attacks deal [%] more damage. For every stack of debuffs on the target, the damage is increased by an additional [%]. The combined bonus is capped at [%].
Arkham's Awakening
Arkham's Awakening
At the start of battle, Nurse Harley gains one stack of [Attack Growth] for each [Arkham's Most Wanted] ally present, up to [5] stacks. Each stack increases her Attack by [%] every second, up to a maximum increase of [%]..
Nurse Harley (Harley Quinn)

DC: Dark Legion 2025 DC ©. Software code 2025 FunPlus International AG ©. DC LOGO and all related characters and elements © & ™ DC.